Most Important Publications

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Bornstein SR.Ludwig B, Barthel A, Reichel A, Block NL, Ludwig S, Schally AV, 
Modulation of the pancreatic islet-stress axis as a novel potential therapeutic target in diabetes mellitus.
Vitam Horm. 2014 (PubMed)

Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia-Martin R, Klotzsche-von Ameln A, Gijbels M, Noelle R, Boon L, Hackeng T, Schulte KM, Xu A, Vriend G, Nabuurs S, Chung KJ, Willems van Dijk K, Rensen PC, Gerdes N, de Winther M, Block NL, Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T, Lutgens E.
Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.
Proc Natl Acad Sci U S A. 2014 Feb 3 [Epub ahead of print] (PubMed)

Hamann C, Picke AK, Campbell GM, Balyura M, Rauner M, Bernhardt R, Huber G, Morlock MM, Günther KP, Bornstein SR, Glüer CC, Ludwig B, Hofbauer LC.
Effects of parathyroid hormone on bone mass, bone strength, and bone regeneration in male rats with type 2 diabetes mellitus.
Endocrinology. 2014 Jan 27 [Epub ahead of print] (PubMed)


Graessler J, Bornstein TD, Goel D, Bhalla VP, Lohmann T, Wolf T, Koch M, Qin Y, Licinio J, Wong ML, Chavakis T, Xu A, Shevchenko A, Schuhmann K, Schwarz PE, Schulte KM, Patel A, Bornstein SR.
Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes.
Pharmacogenomics J. 2013 Dec 24 [Epub ahead of print] (PubMed)

Dimas AS, Lagou V, Barker A, Knowles JW, Mägi R, Hivert MF, Benazzo A, Rybin D, Jackson AU, Stringham HM, Song C, Fischer-Rosinsky A, Boesgaard TW, Grarup N, Abbasi FA, Assimes TL, Hao K, Yang X, Lecoeur C, Barroso I, Bonnycastle LL, Böttcher Y, Bumpstead S, Chines PS, Erdos MR, Graessler J, Kovacs P, Morken MA, Narisu N, Payne F, Stancakova A, Swift AJ, Tönjes A, Bornstein SR, Cauchi S, Froguel P, Meyre D, Schwarz PE, Häring HU, Smith U, Boehnke M, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, Quertemous T, Lind L, Hansen T, Pedersen O, Walker M, Pfeiffer AF, Spranger J, Stumvoll M, Meigs JB, Wareham NJ, Kuusisto J, Laakso M, Langenberg C, Dupuis J, Watanabe RM, Florez JC, Ingelsson E, McCarthy MI, Prokopenko I; MAGIC Investigators.
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.
Diabetes. 2013 Dec 2 [Epub ahead of print] (PubMed)

Ludwig B, Reichel A, Steffen A, Zimerman B, Schally AV, Block NL, Colton CK, Ludwig S, Kersting S, Bonifacio E, Solimena M, Gendler Z, Rotem A, Barkai U, Bornstein SR.
Transplantation of human islets without immunosuppression.
Proc Natl Acad Sci U S A. 2013 Oct 28 [Epub ahead of print] (PubMed)

Müller G, Parfentyeva E, Olschewsky J, Bornstein SR, Schwarz PE.
Assessment of small fiber neuropathy to predict future risk of type 2 diabetes.
Prim Care Diabetes. 2013 Sep 27 [Epub ahead of print] (PubMed)

Phieler J, Chung KJ, Chatzigeorgiou A, Klotzsche-von Ameln A, Garcia-Martin R, Sprott D, Moisidou M, Tzanavari T, Ludwig B, Baraban E, Ehrhart-Bornstein M, Bornstein SR, Mziaut H, Solimena M, Karalis KP, Economopoulou M, Lambris JD, Chavakis T.
The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance.
J Immunol. 2013 Sep 16. [Epub ahead of print] (PubMed)

Neufeld T, Ludwig B, Barkai U, Weir GC, Colton CK, Evron Y, Balyura M, Yavriyants K, Zimermann B, Azarov D, Maimon S, Shabtay N, Rozenshtein T, Lorber D, Steffen A, Willenz U, Bloch K, Vardi P, Taube R, de Vos P, Lewis EC, Bornstein SR, Rotem A.
The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs.
PLoS One. 2013 Aug 1. (PubMed)

Saha S, Graessler J, Bornstein SR, Schwarz PE, Kopprasch S.
Stimulation of phagocyte adhesion to endothelial cells by modified VLDL and HDL requires scavenger receptor BI.
Mol Cell Biochem.  2013 Jul 14. [Epub ahead of print] (PubMed)

Tsourdi E, Barthel A, Rietzsch H, Reichel A, Bornstein SR.
Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus.
Biomed Res Int. 2013 Apr 7. [Epub ahead of print] (PubMed)

Reichel A, Rietzsch H, Ludwig B, Röthig K, Moritz A, Bornstein SR.
Self-adjustment of insulin dose using graphically depicted self-monitoring of blood glucose measurements in patients with type 1 diabetes mellitus.
J Diabetes Sci Technol. 2013 Jan 1;7(1):156-62. (PubMed)

Schubert U, Schmid J, Lehmann S, Zhang XY, Morawietz H, Block NL, Kanczkowski W, Schally AV, Bornstein SR, Ludwig B.
Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth-hormone-releasing hormone.
Proc Natl Acad Sci U S A. 2013 Jan 23. [Epub ahead of print] (PubMed)



Saha S, Schwarz PE, Bergmann S, Bornstein SR, Graessler J, Kopprasch S. Circulating very-low-density lipoprotein from subjects with impaired glucose tolerance accelerates adrenocortical cortisol and aldosterone synthesis. Horm Metab Res.  2012 Oct 9. [Epub ahead of print] (PubMed)

Barkai U, Weir GC, Colton CK, Ludwig B, Bornstein SR, Brendel MD, Neufeld T, Bremer C, Leon A, Evron Y, Yavriyants K, Azarov D, Zimermann B, Maimon S, Shabtay N, Balyura M, Rozenshtein T, Vardi P, Bloch K, de Vos P, Rotem A.
Enhanced oxygen supply improves islet viability in a new bioartificial pancreas.
Cell Transplant. 2012 Oct 3. [Epub ahead of print] (PubMed)

Graessler J, Qin Y, Zhong H, Zhang J, Licinio J, Wong ML, Xu A, Chavakis T, Bornstein AB, Ehrhart-Bornstein M, Lamounier-Zepter V, Lohmann T, Wolf T,Bornstein SR.
Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters.
Pharmacogenomics J. 2012 Oct 2. [Epub ahead of print] (PubMed)

Chatzigeorgiou A, Karalis KP, Bornstein SR, Chavakis T.
Lymphocytes in obesity-related adipose tissue inflammation.
Diabetologia. 2012 Jun 26. [Epub ahead of print] (PubMed)

Pistrosch F, Passauer J, Herbrig K, Schwanebeck U, Gross P, Bornstein SR.
Effect of thiazolidinedione treatment on proteinuria and renal hemodynamic in type 2 diabetic patients with overt nephropathy.
Horm Metab Res. 2012 Jun 21. [Epub ahead of print] (PubMed)

Ludwig B, Rotem A, Schmid J, Weir GC, Colton CK, Brendel MD, Neufeld T, Block NL, Yavriyants K, Steffen A, Ludwig S, Chavakis T, Reichel A, Azarov D, Zimermann B, Maimon S, Balyura M, Rozenshtein T, Shabtay N, Vardi P, Bloch K, de Vos P, Schally AV, Bornstein SR, Barkai U.
Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist.
Proc Natl Acad Sci USA. 2012 Mar 5. [Epub ahead of print] (PubMed)


Ehret GB et al.
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Nature. 2011 Sep 11;478(7367):103-9. (PubMed)

Bornstein SR et al.
Improving the efficacy of translational medicine by optimally integrating health care, academia and industry.
Nature Med 2011; 17:1567-9. (PubMed)


Dupuis J et al.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Nat Genet. 2010 Feb;42(2):105-16. (PubMed)


Bornstein SR.
Predisposing Factors for Adrenal Insufficiency.
N Engl. J. Med. 2009 May 28;360(22):2328-39; (PubMed)


Bornstein SR et al.
Dissociation of ACTH and glucocorticoids.
Trends Endocrinol Metab. 2008, 19: 175-80. (PubMed)


Sicard et al.
Age-dependent regulation of chromaffin cell proliferation by growth factors, dehydroepianddrosterone (DHEA), and DHEA sulphate.
Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2007-12; (PubMed)


Merke DP et al.
Congenital adrenal hyperplasia.
Lancet. 2005, 365: 2125-36. (PubMed)


Schott M et al.
Acquired and inherited lipodystrophies.
N Engl. J. Med. 2004;351(1):103-4.; (PubMed)


Bornstein SR et al.
Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic acid transporter (SVCT2).
FASEB J 2003;17:1928-1930; (PubMed)

Ehrhart-Bornstein M et al.
Human Adipocytes Secrete Mineralocorticoid Releasing Factors.
Proc Natl Acad Sci USA 2003;100:14211-14216;


Galon J et al.
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells.
FASEB J 2002;16:61-71; (PubMed)

Merke D et al.
Future Directions in the Study and Management of Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency.
Ann Intern Med 2002;136:320-34. (PubMed)

Alesci S et al.
Corticotropin releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes.
Proc Natl Acad Sci U S A 2002;99:7484-7489; (PubMed)


Bornstein SR et al.
Immunohistochemical and ultrastructural immunolocalization of leptin and leptin receptor in human white adipose tissue.
Diabetes 2000;49:532-538;

Bornstein SR et al.
Plasma dehydroepiandrosterone (DHEA) levels during acute experimental endotoxemia and antiinflammatory therapy in humans.
Crit Care Med 2000;28:2103-2106;

Franchimont D et al.
Adrenocortical activation in murine colitis.
Gastroenterology 2000;119:1560-1568;

Merke DP et al.
Adrenomedullary dysplasia and hypofunction in patients with congenital hyperplasia
N Engl. J. Med. 2000;343:1362;

Bornstein SR et al.
Haploinsuffciency of SF-1 in mice leads to adrenal dysgenesis and an impaired stress response.
Proc Natl Acad Sci USA 2000;97:14742-14747;


Bornstein SR. et al.
Adrenomedullary function is severely impaired in 21-OH deficient mice.
FASEB J 1999; 13:1185-1194

Hilbers U. et al.
A local renin-angiotensin system is involved in K+-induced aldosterone secretion from human adrenocortical NCI-H295 cells.
Hypertension 1999; 33:1025-1030

Bornstein SR. et al.
Adrenocortical tumors: Recent advances in basic concepts and clinical management.
Ann Intern Med 1999; 130:757-765

Tajima T. et al.
Restoration of adrenal steroidogenesis by adenoviral mediated transfer of human cytochrome P450 21-hydroxylase into the adrenal gland of 21-hydroxylase deficient mice.
Gene Therapy 1999; 6:1898-1903


Bornstein SR. et al.
Chronic effects of a nonpeptide corticotropin-releasing hormone type I receptor antagonist on pituitary-adrenal function, body weight, and metabolic regulation.
Endocrinology 1998; 139:1546-1555

Bornstein SR. et al.
Circulating leptin levels during acute experimental endotoxinemia and anti-inflammatory therapy in humans.
J Infect Dis 1998; 178:887-890

Willenberg HS. et al.
Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome.
N Engl J Med 1998; 339:27-31

Ehrhart-Bornstein M. et al.
Intra-adrenal regulation of adrenocortical function.
Endocr Rev 1998; 30:416-420


Bornstein SR. et al.
Is leptin a stress related peptide?
Nat. Med. 1997; 3:937

Bornstein SR. et al.
Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland. Leptin inhibits cortisol release directly.
Diabetes. 1997; 46:1235-1238


Bornstein SR. et al.
Intimate contact of chromaffin and cortical cells within the human adrenal gland forms the cellular basis for important intraadrenal interactions.
J Clin Endocrinol Metab. 1994; 78:225-232


Bornstein SR. et al.
Effects of splanchnic nerve stimulation on the adrenal cortex may be mediated by chromaffin cells in a paracrine manner.
Endocrinology. 1990; 127:900-906